HIV Pre exposure prophylaxis (PrEP)

What is PrEP?

PrEP is a medication which can be taken to prevent HIV transmission and is available on the NHS for people who are at high risk of contracting HIV.

Taking PrEP before being exposed to HIV means there’s enough drug inside you to block HIV if it gets into your body.

The medication used for PrEP is a tablet which contains Tenofovir and Emtricitabine (drugs commonly used to treat HIV).

It is sometimes called Truvada but most of the PrEP we use in the UK is generic PrEP.

Who can use PrEP?

People who may be eligible to take PrEP include:

• Men who have anal sex with Men without using condoms
• Trans women who have Anal sex without using condoms
• People who have a partner who is HIV + and has a viral load above 40 and have sex without using condoms.

Other groups who may be at high risk of HIV would be considered on a case by case basis, as a decision would be made about whether they would benefit from PrEP.

These people may include:

• Commercial Sex Workers
• People who inject drugs

Some people will not be able to take PrEP because of their medical history.

These include people:

• Who are HIV+
• Who have an acute Hepatitis B infection
• Who are immunosuppressed
• Who are pregnant or breastfeeding
• Who have liver failure or a serious liver condition
• Who have Osteoporosis
• Who are allergic to Tenofovir or Emtricitabine
• Who are taking a medication which may interact with PrEP

How to take PrEP

There are two methods which people can use:

• Daily dosing – One tablet taken daily at the same time each day
• Event based dosing- Medication is only taken when needed (two tablets two to 24 hours before sex, one tablet 24 hours after sex and daily until 48 hours without sexual activity have passed.

Both methods have been shown to be very effective, although on-demand dosing has only been studied in gay and bisexual men.

Daily dosing is recommended for women who need to take PrEP every day for seven days to be protected against HIV.

Daily PrEP is recommended for all Trans people using hormone treatment as there isn’t sufficient data to support other dosing options.

Is PrEP safe?

If you’re thinking about purchasing  PrEP privately , it’s important that you talk to an adviser from a sexual health clinic. They will support you to use the treatment safely and provide necessary tests.

In the studies that have been performed across the world, no participants contracted HIV as long as they took their PrEP correctly.

The medication is very safe and has few side effects.

A few people experience nausea, headaches or tiredness and, very rarely, the medication can affect kidney function. As a precaution, people taking PrEP have their liver function tested every year.

Although PrEP is very effective at preventing HIV from being passed on, it doesn’t protect against any other STIs, unlike using condoms.

It is therefore important that anyone taking PrEP has a regular STI check every 3 months as this will allow any infections to be diagnosed and treated quickly.

If you would like to discuss PrEP, please go to our online service which can assess and deliver PrEP to your chosen address All about PrEP — SH.UK

Alternatively, if you prefer a local face to talk to or prefer a face to face appointment,  please contact your local Sexual Health Clinic and make an appointment to speak to a member of the Health Adviser team. Both services can assess whether PrEP is right for you and give advice and support in making sure People take PrEP safely.

Online prep is available through All about PrEP — SH.UK

Further information is also available from the following websites:

NHS

I want PrEP now

THT